This work aimed to evaluate the effects of oven-dried and smoked-dried on nutrient qualities, quality deterioration and microbiological safety of African catfish (Clarias gariepinus) at various storage condition (1^st, 14^th, 28^th and 42^nd Day). Live fish samples were obtained from Klassik Integrated Aquafarm, Ado Ekiti, Nigeria. Two equal portions were separated from the fish specimens. A smoking kiln was used to dry one portion, while a drum kiln was used to dry the other. Proximate parameters (protein, lipid and carbohydrate, ash, fibre), quality deterioration and spoilage parameters (TBAR, TVB-N, PV and TMAN) and microbiological parameters (total viable and mould counts) were determined for the oven-dried and smoked products stored at different storage condition using standard methods. According to the proximate assessment of the oven-dried products under 42 days storage conditions, the moisture content ranged between 4.34 and 13.02%, crude protein ranged between 60.24 and 72.84%, fibre ranged between 0.16 2.08%, fat 14.62 and 16.82%, ash 5.44 and 9.04%. TVB-N value ranged between 8.67 and 14.06mgN/100 g, PV 1.08 and 6.14 meq, TBAR 0.98 and 2.04 mgMA/kg and TMA-N 2.22 and 3.96 mgN/100 g. TVC ranged between 1.34 and 1.52x103 cfu/g and yeast and mould count 1.16 and 3.88x102cfu/g. Considering all the parameters, it can be concluded that the oven-dried products maintained its excellent nutrients quality under 42 days storage condition while there were significant reduction in nutrients quality, quality deterioration and spoilage, high microbial loads were evidence at 28 days storage condition in smoked products.