The detergents are household chemical cleaning compound used in wide range of our daily life for diverse purposes. Wheel is a common detergent produced and used largely in Bangladesh. Some of the detergent constituents show high biological activity and has a tendency to accumulate in organisms, making adverse effects possible even at very low level of exposure. The freshwater fish like Channa punctatus (Bloch, 1793) is highly sensitive to the household detergents like wheel powder. The average mortality in each concentration was taken to determine by plotting a graph, taking time on X- axis and mortality on Y-axis. According to graphical plots the 100% mortality values of wheel powder for 3 hours 5gm/L. In this concentration fishes show abnormal behaviour, quick movement and histological slide shows decrease of the amount of the abdomen villi. The fish demonstrated various abnormal behaviour in other concentrations also.