Author(s): Madhulita Patnaik, Priyanka C Nandanpawar, Khuntia Murmu, Avinash Rasal and Kanta Das Mahapatra

Abstract: Antibiotics have acted as a boon for treatment of infectious diseases. Nowadays, antibiotic usage is restricted due to the development of antibiotic resistance and indiscriminate extermination of both beneficial and pathogenic bacteria. Antibiotics pose a threat to the digestive system leading to weakened immunity by eradication of beneficiary bacteria. The emergence and increasing prevalence of multidrug-resistant bacteria pathogens in aquatic system emphasizes the need of innovative antimicrobial strategies to combat the currently shrinking therapeutic options against the antibiotic-resistant bacteria. Microbiologists have thus developed a ‘smart bomb’ technique that can serve as a best alternative to the menace by identifying and eliminating the specific pathogenic strains by exploiting the novel strategy of CRISPR-Cas system. This targeted approach is gaining new insights inviting extensive research and practical implications in allied sectors. This article suggests the potentiality of this nascent technique in conferring a promising and propitious contribution to the aquaculture domain against the perilous fish bacterial diseases.

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