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International Journal of Fisheries and Aquatic Studies
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(ICV-Poland) Impact Value: 76.37, Impact Factor: RJIF 5.69
E-ISSN: 2347-5129, P-ISSN: 2394-0506

International Journal of Fisheries and Aquatic Studies

2017, Vol. 5, Issue 3, Part B

Toxicity of diazepam on lipid peroxidation, biochemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus (Burchell, 1822)


Author(s): Emmanuel O Ogueji, Stanley C Iheanacho, Christopher D Nwani, Christian E Mbah, Ogochukwu C Okeke, and Ibrahim B Usman

Abstract: The present study assessed the toxic effects of Diazepam (Valinex - 5) on liver and gill tissues of Clarias gariepinus. Fish were exposed to sublethal concentrations of 2.67, 5.34, 10.68, 21.36, and 42.72mg.L-1 for 28days. Liver and gill tissues were sampled on day 7, 14, 21 and 28. Results showed that lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPx) in both tissues was significantly (p<0.05) elevated in the treated groups when compared to control. LPO, SOD, CAT and GPx showed tissue specific response to diazepam as their activities were more pronounced in the gill than the liver during the experimental run. Diazepam elicited in both tissues significantly (p<0.05) decreases in glucose and protein. Changes in the antioxidant enzyme activities indicated that Diazepam caused oxidative damage in the tissues. The formation of oxygen radicals might be a factor in the toxicity of Diazepam

Pages: 114-123  |  572 Views  25 Downloads

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How to cite this article:
Emmanuel O Ogueji, Stanley C Iheanacho, Christopher D Nwani, Christian E Mbah, Ogochukwu C Okeke,, Ibrahim B Usman. Toxicity of diazepam on lipid peroxidation, biochemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus (Burchell, 1822). Int J Fish Aquat Stud 2017;5(3):114-123.
International Journal of Fisheries and Aquatic Studies