International Journal of Fisheries and Aquatic Studies
2017, Vol. 5, Issue 2, Part I
Biological activities of some marine sponge extracts from Aqaba Gulf, Red Sea, Egypt
Author(s): El-Damhougy KA, Hussein A El-Naggar, Hassan AH Ibrahim, Mansour AE Bashar and Fekry M Abou Senna
Abstract: Two marine sponge species (
Grayella cyathophora and
Negombata magnifica) were collected during winter 2016 from Gulf of Aqaba, Red Sea, Egypt. The sponge samples were investigated as a promising source of natural products which can be used as antitumor, antiviral, antimicrobial, antioxidant, and anti-inflammatory agents. The present results revealed that the crude extract of
G. cyathophora showed the high cytotoxic effect to Vero cell with hepatitis A virus which exhibits that Minimum inhibitor concentration was 2.929µg/ml. Also, it showed positive antibacterial activity against
P. aeruginosa and the antioxidant activity compared to standard ascorbic acid was very weak with a value of 748μg / mL as IC
50 and the activity of this anti-inflammatory extract was also (89.91%).At the same time, the crude extract of
N. magnifica showed high antitumor activity with value of 1.09µg/ml and 0.37 µg/ml as IC
50 against colon cancer (caco-2) and breast cancer (Mcf-7) on cell line, respectively, it does not possess any effect as an antiviral, antibacterial, anti-inflammatory and antioxidant activities
. Generally, the present results confirmed that the ethanolic crude extract of
N. magnifica conducted to promising antitumor agent and that of
G. cyathophora conducted to promising anti-inflammatory and antiviral agents.
Pages: 652-659 | 1393 Views 289 DownloadsDownload Full Article: Click Here
How to cite this article:
El-Damhougy KA, Hussein A El-Naggar, Hassan AH Ibrahim, Mansour AE Bashar, Fekry M Abou Senna. Biological activities of some marine sponge extracts from Aqaba Gulf, Red Sea, Egypt. Int J Fish Aquat Stud 2017;5(2):652-659.
