Author(s): Imtiyaz Ahmad Bhat

Abstract: The liver of Labeo rohita was histopathologically examined after acute exposure (4 days) and chronic exposure (30 days) of two sublethal concentrations (1/15^th and 1/10^th of 96h LC₅₀ values) of Kethrin. After the acute exposure of 1/15^th (1.445ppm) and 1/10^th (=2.168ppm) of 96hr LC₅₀ value of Kethrin to L. rohita for 4 days, histopathological changes observed includes severe necrosis, cloudy swelling of hepatocytes and disintegration of liver lobules. After the chronic exposure of 1/15^th of LC₅₀ (1.445ppm) and 1/10^th (=2.168ppm) of LC₅₀ value of Kethrin to L. rohita for 30 days, histopathological changes observed includes necrosis, cloudy swelling, hyperplasia, coagulation of blood vessel, lifting up of epithelium and infiltration of lymphocytes. The histopathological damage in the liver was found to be severe in case of chronic exposure as compared to the acute exposure of Kethrin. The results indicate that even the sublethal concentrations of Kethrin were enough to elicit significant changes in the liver histology of L. rohita and further suggest that even smaller concentrations of any toxicant in the environment can induce major histological changes and more care and vigil is needed before using such biopesticides into agricultural fields or near fish farms.

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