Author(s): K. Ramalingam, U.D. Bharathi Rajan, R. Karthik, R. Muthezhilan

Abstract: The present investigation was aimed to determine the antibacterial effectiveness of the serum of Scylla tranquebarica challenged with Pseudomonas aeruginosa ATCC 27853 in two forms viz., heat killed form and live form. The antibacterial activity was discernible only in the heat killed group exhibited the antibacterial activity after 48 hours. After 96 hours the sham control showed again a significant antibacterial activity. Throughout the test period of 96 hours, the live group serum failed to show the antibacterial activity. In order to study the secondary response, the three groups were inoculated with a secondary dose of saline, heat killed (10-7) and live (10-7). The results revealed that no significant response was discernible in all the three groups. After 72 hours the immunoreactivity of these peptides became undetectable in tissue like gills as well as in the cuticle infiltrating hemocytes. From these studies, it is understood that antimicrobial peptides is a local protection system to prevent invasive infectious pathogens such as bacteria, fungi and also play role in wound healing and during injury.

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