International Journal of Fisheries and Aquatic Studies
2017, Vol. 5, Issue 3, Part B
Toxicity of diazepam on lipid peroxidation, biochemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus (Burchell, 1822)
Author(s): Emmanuel O Ogueji, Stanley C Iheanacho, Christopher D Nwani, Christian E Mbah, Ogochukwu C Okeke, and Ibrahim B Usman
Abstract: The present study assessed the toxic effects of Diazepam (Valinex - 5) on liver and gill tissues of
Clarias gariepinus. Fish were exposed to sublethal concentrations of 2.67, 5.34, 10.68, 21.36, and 42.72mg.L
-1 for 28days. Liver and gill tissues were sampled on day 7, 14, 21 and 28. Results showed that lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPx) in both tissues was significantly (
p<0.05) elevated in the treated groups when compared to control. LPO, SOD, CAT and GPx showed tissue specific response to diazepam as their activities were more pronounced in the gill than the liver during the experimental run. Diazepam elicited in both tissues significantly (
p<0.05) decreases in glucose and protein. Changes in the antioxidant enzyme activities indicated that Diazepam caused oxidative damage in the tissues. The formation of oxygen radicals might be a factor in the toxicity of Diazepam
Pages: 114-123 | 1045 Views 101 DownloadsDownload Full Article: Click Here
How to cite this article:
Emmanuel O Ogueji, Stanley C Iheanacho, Christopher D Nwani, Christian E Mbah, Ogochukwu C Okeke,, Ibrahim B Usman. Toxicity of diazepam on lipid peroxidation, biochemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus (Burchell, 1822). Int J Fish Aquat Stud 2017;5(3):114-123.
