Author(s): Fathy M Elshaer

Abstract: The present work aimed to investigate the acute histopathological effects of tetrodotoxins (TTX) extracts of gonads (ovary) and muscles of the porcupine fish, Diodon hystrix on the kidney and liver of male albino rats. The porcupine fishes were collected from the Egyptian Red Sea coast at Hurgada. A sub-lethal dose of each tetrodotoxin extract was intraperitoneally injected to male albino rats, and samples of liver and kidney were obtained 2 and 4 hours after injection. The results showed that severe histopathological effects recorded in both kidney and liver of male rat injected with TTX which extracted from ovary and muscles, represented by shrinkage of glomeruli, glomerular distortion, necrotic renal tubules, severe congestion and atrophy of renal tubules, necrotic hepatocytes, and congestion in central vein. While TTX which extracted from muscles, showed that moderate histopathological effect in both kidney and liver represented by shrinkage of glomeruli, increased of bowman space, fatty change liver and congestion in central vein. Conclusively, this study proves that, the gonads, particularly ovaries of puffer fish, are more toxic than muscle and TTX from these marine can produce surplus detrimental effects when it enters directly in the blood tissues of living organisms and the degree of damage varies in intensity according with the duration of exposure.

Pages: 355-360  |  1347 Views  143 Downloads

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