International Journal of Fisheries and Aquatic Studies
2015, Vol. 3, Issue 2, Part F
Differential expression of heat shock proteins in fish hepatocytes under hypoxic condition
Author(s): Ekambaram Padmini, Jayachandran Tharani
Abstract: Hypoxia in estuarine ecosystems is a problem of growing concern worldwide. Induction of signaling molecules (HSPs) is a crucial step in the cellular response to stress. Altered expression of such proteins in response to stress conditions is a key factor for the maintenance of cellular integrity and survival. This is the first study that attempts to confirm the role of HSPs in fish hepatocytes using
in-vitro (induced) and
in-vivo (natural) hypoxic conditions. The level of HNE, GRD, HIF1α, HSP70, HO-1, CYP1A2 and ASK1 were measured in the hepatocytes of
Mugil cephalus inhabiting control and test sites with and without
in-vitro hypoxic incubation. The oxidant-antioxidant status, heat shock proteins and its associated signaling molecules were differentially expressed in fish hepatocytes inhabiting pollutants induced hypoxic condition and
in-vitro hypoxic incubation. The present
in-vitro hypoxic incubation studies suggest that HSPs may play a protective role in the
Mugil cephalus surviving in polluted waters.
Pages: 447-455 | 1333 Views 123 DownloadsDownload Full Article: Click Here
How to cite this article:
Ekambaram Padmini, Jayachandran Tharani. Differential expression of heat shock proteins in fish hepatocytes under hypoxic condition. Int J Fish Aquat Stud 2015;3(2):447-455.
