Contact: +91-9711224068
International Journal of Fisheries and Aquatic Studies
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal

(ICV-Poland) Impact Value: 76.37, Impact Factor: RJIF 5.69
E-ISSN: 2347-5129, P-ISSN: 2394-0506

International Journal of Fisheries and Aquatic Studies

2015, Vol. 3, Issue 2, Part F

Differential expression of heat shock proteins in fish hepatocytes under hypoxic condition


Author(s): Ekambaram Padmini, Jayachandran Tharani

Abstract: Hypoxia in estuarine ecosystems is a problem of growing concern worldwide. Induction of signaling molecules (HSPs) is a crucial step in the cellular response to stress. Altered expression of such proteins in response to stress conditions is a key factor for the maintenance of cellular integrity and survival. This is the first study that attempts to confirm the role of HSPs in fish hepatocytes using in-vitro (induced) and in-vivo (natural) hypoxic conditions. The level of HNE, GRD, HIF1α, HSP70, HO-1, CYP1A2 and ASK1 were measured in the hepatocytes of Mugil cephalus inhabiting control and test sites with and without in-vitro hypoxic incubation. The oxidant-antioxidant status, heat shock proteins and its associated signaling molecules were differentially expressed in fish hepatocytes inhabiting pollutants induced hypoxic condition and in-vitro hypoxic incubation. The present in-vitro hypoxic incubation studies suggest that HSPs may play a protective role in the Mugil cephalus surviving in polluted waters.

Pages: 447-455  |  724 Views  11 Downloads

Download Full Article: Click Here

How to cite this article:
Ekambaram Padmini, Jayachandran Tharani. Differential expression of heat shock proteins in fish hepatocytes under hypoxic condition. International Journal of Fisheries and Aquatic Studies. 2015; 3(2): 447-455.
ADVERTISEMENT
Mosquito Journal
Call for book chapter
Journals List Click Here Research Journals Research Journals